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KMID : 0861020120270010011
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Korea Journal of Herbology
2012 Volume.27 No. 1 p.11 ~ p.16
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Effects of pear ethanol extract on asthma induced by ovalbumin in mice
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Jeong Hui-Jin
Joung Young-Min
Choi Eu-Gene
Shin Dong-Sun
Kim Hyung-Woo
Cho Su-In
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Abstract
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Objectives: In the theory of Korean medicine, Pear has long been considered to protect throat, bronchus and
lung. Pear has been believed to remove sputum in Korean people. This study was conducted to investigate the
effect of pear ethanol extract (PEE) on asthma induced by ovalbumin in mice.
Methods: We investigated the effects of PEE on airway hyperresponsiveness to methacholine, production levels
of ovalbumin (OVA) specific total immunoglobulin G (IgG), IgG1, IgG2a and IgE in serum and histopathological
changes of lung tissues in asthamtic mice.
Results: PEE decreased airway hyperresponsiveness to methacholine significantly compared to non-treated
asthmatic mice (P<0.05). Level of OVA specific IgE in serum was lowered by oral administration of PEE
effectively (P<0.05). In histopathological observation, administration of PEE reduced infiltration of immune cells
into lung tissue.
Conclusion: These results suggest that pear has anti-asthmaitc action and related mechanims are involved in
anti-inflammatory action such as reducing level of OVA specific IgE and immune cell infiltration.
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KEYWORD
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Pear, IgE, airway hyperresponsiveness, anti-inflammation, Asthma
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